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ASCEND connects the civil, commercial, and national security space sectors, along with adjacent industries, to embrace the opportunities and address the challenges that come with increased activity in space. Building our sustainable off-world future requires long-term thinking. Strategic planning, innovation, scientific exploration, and effective regulations and standards will help us preserve space for future generations. 2025 ASCEND, hosted 22–24 July in Las Vegas, will enable the technical exchanges, debates, and collaboration that will help forge a sustainable off-world future for all.